Euangelion original explanatory graphic. Created for the October 6, 2026 edition. Author: Euangelion. Copyright: Euangelion, 2026. Permission is granted to reproduce this original graphic with attribution and its complete caption, without implying endorsement. Source basis: https://www.nature.com/articles/s41587-026-03307-w Toy example: twenty positions represent hypothetical genes, three of which change. A flat prediction misses all three changes. Averaging errors across many unchanged genes can dilute that failure. Counts, amplitudes and spacing are illustrative, not results from Shift’s study; no clinical or model-performance gain is plotted. No third-party photograph, figure, artwork or layout is reproduced.